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Insights from these assays mitigate the risk of late-stage conflicting data, drug candidates being wrongly abandoned as toxic or mistakenly classified as safe

Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo Cancer Res 1993 53 : 10231026 Lvay G, Bodell WJ

Cellulose membranes of 3.5 KDa (6.4 mL/cm) were supplied by Spectrum Laboratories, Inc (Rancho Dominguez, USA)

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75 These techniques, however, could not detect DNA interstrand cross-linking in mammalian cells exposed to therapeutic levels of alkylating agents in vitro or in tissues after in vivo drug administration