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In late-stage trials, people taking orforglipron lost an average of about 12% of their body weight over roughly 72 weeks , and head-to-head studies suggest it may outperform standard oral semaglutide tablets (Rybelsus) in both weight loss and blood sugar control

Using a 3 mL dilution , the protocol is designed to support accurate subcutaneous dosing and simple insulin-syringe measurement in research settings