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Experimental data indicate that even brief exposure (e.g., 7 days) can result in a marked increase in sperm morphological abnormalities ( Figure 1a )

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Subsequently, this research demonstrated that the administration of various natural or synthetic antioxidants can be beneficial in preventing or attenuating metal-induced biochemical dysfunctions

The resulting H 2 O 2 , generally, can be compartmentalized or detoxified by catalase, but excessive production may leak into the cytoplasm, affecting nuclear gene expression and cytosolic enzymes through redox modifications (Martemucci et al., 2022)

Around 500 million years ago, coinciding with the colonization of terrestrial environments and the advent of a more complex nervous system during the CambrianDevonian periods, microglia and oligodendrocyte lineages are thought to have emerged (Freeman and Rowitch, 2013)