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When extended to a phase II trial including over 100 patients with AD, those taking the NF not only maintained their cognitive performance (as measured by DRS and CLOX1) after 3 months, but in fact achieved improved scores, with excellent tolerability (22)

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The same researchers conducted a larger intervention in 42 children with autistic disorder who had evidence of reduced methylation capacity or GSH:GSSG in which they were supplemented with folinic acid and methyl-cobalamin for 3 months [48]

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