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Montgomery SL, Bowers WJ (2012) Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system

Curcumin (direct inhibitor of STAT3 and NF-kB activation) 281,282,283 is studied in the combination with PDT and/or PTT/hyperthemia 256,284,285 Curcumin also decreases HSP efficiency in cancer cells 286 (including HSP-70) 256 , effectively suppressing the hypoxic phenotype in tumor tissues and activating the anti-tumor immune system 287,288

pylori both in vitro and in vivo , with mechanisms including the prevention of H

On one hand, they significantly reduced gliosis, cellular pyknosis, and neuronal swelling, while suppressing apoptosis and oxidative stress (96)

Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice