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The loop between TM1 and TM2 forms a lid over the active site in LTC4S and would have to fold away to allow for an extended conformation of GSH

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Terpenoids induce ferroptosis in tumor cells Terpenoids are widely distributed in nature and constitute the main components of fragrances, resins, and pigments in certain plants

And that is very important to understand because its necessary for the health and longevity of your tissue