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56 Studies have shown that Bcl-2 phosphorylation leads to reduced formation of Bax-Bcl-2 heterodimers and activation of the mitochondria-mediated intrinsic caspase cascade

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Fitoterapia 143 , 104553 (2020)

Complex it with a copper 2+ ion, encapsulate it for stability, and you can push the effective hydrodynamic radius well past the cutoff

The methylenetetrahydrofolate reductase enzyme(MTHFR), which is encoded by the MTHFR gene, is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation