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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

2 ounces twice daily by mouth A 500-ml bottle of amino acid-vitamin-electrolyte solution can be given in small doses over a 12-hr period as a drench or added to drinking water