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As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Niu et al., 2021)

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Glutathione is a natural antioxidant found in every cell in the human body, and is composed of three amino acids: cysteine, glutamic acid, and glycine

In relation to COX-2, polyphenols may have several effects: (i) Some studies have suggested that polyphenols may inhibit COX-2 activity [239], and (ii) wine polyphenols have been shown to exert an antineoplastic effect on the androgen-resistant PC-3 cell line through inhibition of NF--mediated transcriptional activity of the COX-2 promoter