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The factors that trigger the development of valve myxomatous degeneration are still unknown, but aberrant TGFB signaling appears to initiate and perpetuate the valve pathology characteristic of this disease in the dog." RETURN TO TOP ---transforming growth factor beta (TGFB) Transforming growth factor beta (TGFB) is a combination of growth factors which are secreted to support cellular growth in dogs and most all other mammals

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