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In humans, chronic HBV infection often shows weak or absent virus-specific T-cell reactivity, which is described as the exhaustion state characterized by poor effector cytotoxic activity, impaired cytokine production and sustained expression of multiple inhibitory receptors, such as programmed cell death-1 (PD-1), lymphocyte activation gene-3, cytotoxic T lymphocyte-associated antigen-4 and CD244

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As an antioxidant, selenium helps fight free radical damage and moderates reactive oxygen species (ROS), which cause cellular oxidative stress

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