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A small portion of glutamate is oxidatively metabolized, thus making synthesis of glutamate necessary to maintain adequate glutamate levels [24]

Dashty M

The accumulation of oxidized lipids, such as prostaglandin E2 (PGE2), fatty acid transport protein 2 (FATP2), and arachidonic acid, also contributes to MDSC-mediated immune suppression through oxidative stress [460]

Therefore, it is conceivable that different cell types, such as hepatocytes and beta cells, have distinct needs for oxidation versus reduction, dependent not only on the types of proteins that a given cell type has to secrete, but also on cellular conditions such as nutrient fluxes that impact the relative composition of the secretome at any given time

J Musculoskelet Neuronal Interact