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Intrinsic and extrinsic factors may cause damage to sperm DNA

Medications: Certain long-term medications can interfere with glutathione production or increase its consumption

In the ICH disease model, the role of GSH was first revealed by the team led by Dhandapani, who successively reported that GSH depletion leads to cell damage and death in hemin-induced astrocytes and endothelial cells (Laird et al., 2008