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This leads to regions of tumors that are hypoxic, and, in turn, to regions where the extracellular pH is relatively low because of the production of lactic acid, and to poor clearance of this and other acidic products of metabolism (see Fig

Biselli JM, de Angelo Calsaverini Leal RC, Ruiz MT, Goloni-Bertollo EM, Manglia JV, Rossit AR, et al

50 U, S8160, Sigma-Aldrich) and catalase (2,000 U, C9322, Sigma-Aldrich) to eliminate extracellularly released O 2 and H 2 O 2

It is also key to maintaining normal function of the immune system, because it supports the liver in clearing toxins from the body.