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doi:10.1186/1471-2105-7-386

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Introduction Chemical inducers of proximity (CIPs) include bifunctional small molecules and molecular glues that induce proximity between two targets, often leading to neomorphic effects that can be leveraged to re-wire biological circuits, which is difficult to achieve with other pharmacological approaches 1,4

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In systems comprising relatively polar and relatively non-polar components the hydrophobic tail preferentially interacts with the relatively non-polar component(s) while the hydrophilic head preferentially interacts with the relatively polar component(s)