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Interestingly, the K465R mutation in DYRK1A changes the mode of inhibition of EGCG from a non-competitive to a competitive inhibitor at the ATP site

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Acknowledgements This work was performed as part of the EU COST ACTION, CONNECT (CA 19127) Cognitive Decline in Nephro-Neurology: European Cooperative Target, a European project that aims to coordinate research on cognitive impairment in chronic kidney disease

It is found that JAK1/2 kinases are the primary and nonredundant drivers of the synergistic death of human IECs induced by IFN- and TNF- (128)

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