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Pharmacologically, modulating histone acetylation with LAC rapidly increased xCT and activated a network with mGlu2 receptors to prime enhanced glutamate homeostasis that promotes both pro-resilient and antidepressant-like responses (101)

Naftidrofuryl, a 5-hydroxytryptamine serotonin receptor inhibitor, has been available in Europe for a number of years and has shown some efficacy in improving claudication symptoms

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It was demonstrated that ALC facilitates cholinergic neurotransmission directly or by providing an acetyl group that may be used for acetylcholine synthesis [17,18]

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