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DOI:10.1007/s10620-009-0971-5 [ Links ] 49

Conversely, the co-expression of the CA variant Cdc42 G12V rescued the ciliary resorption inhibition caused by MAST4 R503A and MAST4 D504A (Fig 5B)

For example, prolonged ferroptosis inhibition may promote tumorigenesis (by suppressing cell death in pre-malignant cells) or exacerbate other pathological processes (e.g., fibrosis) in ADPKD kidneys, risks that require rigorous evaluation in long-term animal models

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However, we should realize that to identify a given agent as a thyroid disruptor (and also any EDC) meets numerous difficulties, for example, exposure to usually only one (or just a few chosen) potential EDC under experimental conditions, and even our still limited knowledge regarding physiological processes in the thyroid resulting in diagnostic doubts which thyroid hormone concentration is normal or abnormal, etc