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Molecular Formula : CHN Molecular Weight : 159.21 g/mol PubChem CID : 950107 CAS Number : 42464-96-0 Synonyms : 5-amino-1-methylquinolinium Source: PubChem NNMT catalyzes the methylation of nicotinamide, a key precursor in the NAD+ salvage pathway

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employed in osteoarthritis and cartilage regeneration research Pigs Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys 9-month chronic toxicology studies via oral gavage Human subjects Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development

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Their work found and described several selective NNMT inhibitors, including 5-amino-1-methylquinolinium derivatives