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Glucose metabolism impairment is involved in the pathogenesis of PD Diabetes mellitus (DM) and PD share some pathophysiological mechanisms, such as oxidative stress, mitochondrial dysfunction, neuroinflammation, insulin resistance, and protein misfolding [59]

Thus, ferritin abundance controls ferroptosis sensitivity: ferritin raises the susceptibility to ferroptosis when unstable iron pools are limited because it promotes iron ion preservation

Furthermore, C3 inhibitors such as the compstatin analog AMY-101, by blocking C3 convertase, reduced kidney damage and systemic inflammation in hemorrhagic shock models

leukopenia Platelets , or thrombocytes , are involved in the formation of blood clots (ASH 2011)