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Unlike DSIP, Z-drugs have well-established efficacy but carry risks of tolerance, dependence, cognitive impairment, and residual daytime sedation

These links reflect shared immunogenetic factors, including IL-18, IFN-, CTLA-4, HLA-DQ8, HLA-DQ2, HLA-B8, and HLA-DR3, many of which are integral to antigen presentation within the major histocompatibility complex (MHC)

It was specifically derived from amino acids 176-191

Researchers reference them in the same sentence, cite each others data across both compounds, and occasionally order one when they mean to study the other

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