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In addition, patients may experience decreased sensitivity to light and sound which often accompanies migraine attacks

107,108 Further, gluconeogenesis suppression by insulin is mediated by inhibition of FOXO1 transcription factors

Such information may support more individualised treatment strategies, including dose adaptation in radiotherapy, early modification of systemic therapy regimens, or selection of patients for hypoxia-targeted or metabolism-modulating therapies

In transplantation, cold ischaemia, a surgical technique, involves organs cooling after blood supply has been cut off to reduce the organ metabolism and oxygen consumption, but the subsequent reperfusion contributes to graft dysfunction and rejection [10]

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