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MSEA (Table 3) linked alanine, glycine and pyroglutamic acid with a significant alteration of glutathione metabolism (p = 98% of samples

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Focusing on a fundamental process like redox balance, GR inhibitors may offer a distinct mode of action compared to traditional antibiotics, thereby reducing the risk of cross-resistance

Electroporation with siRNAs was performed with human monocyte-derived macrophages, which were differentiated for 7 days in RPMI1640 supplemented with 2% AB-serum, penicillin (100 U/mL), streptomycin (100 g/mL), 2 mM L-glutamine and 2% pooled human serum