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In addition to fluid secretion, LT can reshape epithelial programs in the small intestine in vivo, supporting broader enteropathic effects that may aggravate inflammation when mucosal defences are weakened 125

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The manufacturer explicitly advises keeping the vial in the carton to shield it from light

Biologically plausible domain of applicability All the key events described should be conserved among animal species, suggesting that the AOP may also have relevance for amphibians, reptiles, birds and and invertebrates with sexual reproduction

To date, however, most of the aforementioned results have come from animal models, with limited human randomized controlled trials