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10.1038/nrmicro2070 Nat

The first patient, treated in 1906, was a 50 year old dying man who had just had his toe amputated due to gangrene from diabetes and was in a diabetic coma

Well fix it, fast

During the remodeling phase, the maturation and remodeling of the extracellular matrix (ECM) contribute to improved tissue architecture and enhanced connectivity, promoting the generation of higher-quality tissue