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NPAS4 is a neuroprotective protein and acts as a TF, regulating the transcription of a diverse set of genes involved in synaptic plasticity, neurotransmission, and neuronal survival 58

In vitro , an overexpression of the Nrf2 system has been shown to up-regulate the activity of the promoter of the cystine/glutamate antiporter xCT in several types of cells (Habib et al., 2003)