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128 In summary, accumulating research into these common pathophysiologic mechanisms will enhance our comprehension of ASD diagnosis and treatment, while provide insight into general or subgroupspecific processes that may contribute to the development of ASD and other psychiatric disorders

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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies