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Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation

Cell 118:781794 Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL (2013) Hypoxia-inducible f0actor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts