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It is not entirely clear how these agents induce apoptosis

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The resulting hypoxia, together with nitroreductase and bioreductants, drives amphiphilic alginate to reduce nitroimidazole into hydrophilic aminoimidazole, disrupting capsule amphiphilicity and triggering insulin release

ADE risks could increase in the time period where mAb concentrations have waned below a threshold for protection (which is analogous to the historical motherinfant data that provided important clinical evidence for ADE in dengue 83 )