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High variety of flavonoids and their modification (Williams and Grayer, 2004) and the absence of universality of flavonoid modifications in different plant species ( After completion of biosynthesis, secondary metabolites like GSLs and flavonoids, which are present at high concentrations in the cell, need to be imported into the vacuole ( Figure 2 , the identity is unknown), stored there or further metabolized and/or transported ( Figure 3 , transporters 16 and 17)

Materials and methods Institutional Review Board approval was obtained at the University of Washington for this single-center study of 15 participants with mid-stage PD

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The size of nickel purified GST-GFP eluted with imidazole (Figure 4A, green arrow) is half the size of GST-GFP eluted with glutathione (Figure 4A , red arrow)

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