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MOTS-C supports muscle protein synthesis and metabolic health, helping maintain lean muscle mass during aging and supporting healthy body composition and physical function

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p53 deficiency in AgRP neurons significantly induces an obese phenotype characterized by mild hyperphagia, elevated adiposity, and decreased energy expenditure under conditions of excess nutrition

This involves replacing the unknown counterfactuals, or treatment effectiveness among those for whom assigned treatment is different from the treatment actually taken, with a range of values these unknown counterfactuals can take