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Sappanone A similarly combats inflammation and ECM degradation in OA by attenuating chondrocyte ferroptosis through the SIRT1/Nrf2 pathway (165)

Int J Neuropsychopharmacol (2007) 10:54755.10.1017/S1461145706007322 163 VostrikovVMUranovaNAOrlovskayaDD

doi: 10.1016/j.heares.2022.108489, 22 CederrothC

Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism