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Drugs and Toxins that Produce Delayed Toxicities General Principles of Pharmacology: Drug Metabolism Hepatic Cytochrome P450 Enzyme Families: Drug Metabolism The liver plays a central role in drug metabolism, with the Cytochrome P450 (CYP450) enzyme system driving the oxidative transformation of countless medications and does lidocaine use glutathione or glucuronidation Medicinal chemistry on metabolism(Phase I & Phase II Reactions) Chronic alcoholism lowers the Beta Glucuronidase in the Hydrolysis of Glucuronide Drug Conjugates

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