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Here we show that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis

Among these, the deacetylation of promoter-associated H3K9 and H4K16, along with the resulting transcriptional repression, has been particularly well characterized

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By comparing the two, it becomes exceedingly clear that differing concentrations, durations and fish sizes/maturities has a significant impact on how ammonia influences the GM and should be taken into account when considering studies on this topic