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3.5 Parallel defense pathways: GPX4, DHODH, and FSP1 Although the GPX4GSH axis is widely recognized as the primary defense line against plasma membrane lipid peroxidation and ferroptosis, recent discoveries have identified GPX4-independent parallel defense mechanisms within cells, revealing the complexity and redundancy of the cellular antioxidant network

The slower redistribution of these drugs from adipose tissue to the circulation delays their clearance and extends their pharmacodynamic effects (Adamus et al

Mol Neurobiol 58:19051916

Nekoufar S, Fazeli A, Fazeli MR

All animal studies were performed according to the guidelines of the Chinese Council on Animal Care and were approved by the Affiliated Tumor Hospital of Guangxi Medical University Committees on Animal Experimentation (Nanning, China)