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Aid's vascular function & integrity

Macrophages exhibit a heterogeneous and plastic phenotype, capable of polarizing into the pro-inflammatory M1 or the reparative and anti-inflammatory M2 phenotypes

Senescent cells in the scalp essentially poison the follicular environment, secreting pro-inflammatory signals that impair neighboring follicles

The combination of all four pathways should theoretically produce earlier onset of appetite suppression, more sustained fullness between meals, increased resting energy expenditure from the glucagon component, and a reduced tendency toward the metabolic adaptation that commonly causes weight loss plateaus on single-agent therapy