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The platelets -granules and dense granules then release various substances that affect homeostasis

GSTT1-null individuals have reduced capacity to conjugate and excrete these compounds increasing their intracellular residence time and reactivity with DNA and protein

Zhai Y, Zhu C, Zhu T, Song W, Tang Y, Jiang L, Wu Q (2025) Global, regional, and national burden of chronic respiratory diseases, 19902021 and predictions to 2035: analysis of data from the global burden of disease study 2021

These systems are unique in that they have a hydrophobic core that functions as an efficient carrier for the delivery of hydrophobic drugs, Paclitaxel [53], Budesonide [95], and Celecoxib [96], and a very hydrophilic polysaccharide backbone that serves as a shell for such poorly water-soluble pharmaceuticals