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Activation of TGFB/SMAD signaling pathway in HOXC8-imESCs In the TGFB signaling pathway, SMAD2 and SMAD3 are activated via phosphorylation by TGFB receptors and translocated into the nucleus to regulate gene expression 29,30

The fat-soluble components are mainly diterpene quinones include tanshinones and rolitazones [31, 32]