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Additionally, the BCL2 family promotes the transcription of nuclear factor erythroid 2-related factor 2, which initiates an antioxidant response that reduces ROS levels, enhances cellular protection and growth, and contributes to tumor progression and drug resistance (58)

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Schenck et al., 1987

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Decreased steric hindrance and increased hydrophobicity are possible reasons for the improved catalytic efficiency of S586A