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Disruption of redox coupling can be seen in experimental models where astrocyte-specific mutations in the superoxide dismutase gene lead to enhanced motor neuron degeneration, an effect mitigated by mitochondrial-targeted antioxidants like MitoQ (Cassina et al., 2008)

Available at: (Accessed January13, 2023)

Nature 614 , 521529 (2023)

Mechanistically, autoantibodies directed against AMPA-Rs and NMDA-Rs decrease the numbers of the cell-surface receptors [63] and anti-AMPA-RAb may act as agonists and increase cell excitability [66]