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second, at the molecular biology level, this involves epigenetic modifications of drug targets, activation of intracellular drug-metabolising enzymes, and abnormal activation of epithelialmesenchymal transition processes and DNA damage repair pathways regulated by key signalling pathways such as the PI3K/AKT and NF-B pathways [126]

Deursen, Two-step senescence-focused Cancer therapies

Neurology 72, S65S73

Heavy metals also disrupt the guts microbial balance, leading to dysbiosis characterized by a decrease in beneficial microorganisms and proliferation in harmful ones, ultimately exacerbating health problems