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When the therapeutic treatment of T4 was administered after EAE symptoms onset instead of on the day of PLP immunization, functional outcomes revealed that this T4 treatment approach evoked significant functional benefit (Zhang et al., 2016a), and concurrently increased OLs in the demyelinating CNS

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The pathogenesis involves a breakdown of self-tolerance, enhanced antigen presentation, T and B lymphocyte activation, autoantibody production, and cytokine-mediated thyroid tissue damage