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In living cells, the primary determinant of the cellular redox state is the GSH/GSSG ratio and the efficiency of de novo GSH biosynthesis

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doi:10.1177/0004563215610589 pmid:26438522 Hashimoto M, Takenouchi T, Rockenstein E, Masliah E (2003) Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinsons disease