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285 Tryptophan metabolites, such as indole and indole-3-acetic acid, activate aryl hydrocarbon receptor (AhR) to suppress lipogenic genes (e.g., SREBP1c), but microbial imbalance upregulates SREBP2 via tryptophan metabolism, fueling hepatocellular carcinoma (HCC)

Our findings reveal a previously unrecognized role for ORP5 in balancing lipid storage with mitochondrial lipid biosynthesis, highlighting PA transport at the MAMLD junctions as a key mechanism of inter-organelle metabolic coordination

These include proton pump inhibitors (PPIs), antifungals, anti-inflammatory agents, antidiabetics, and antihistamines [121]

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A selective pentapeptide agonist of the ghrelin receptor (GHS-R1a) with high specificity