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Moreover, addition of DEM, a potent thiol-depleting agent, in cell cultures led to I B degradation in TNF- -treated hGH-producing cells (Figure 4D, lower right), while, as expected, a pattern of stabilised I B was shown in U937-hGH cells with an unmodified thiol level (Figure 4D, upper right)

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To test whether GSK3 can phosphorylate STARD3, we treated HCC1954 cells with the GSK3 inhibitor CHIR99021 and examined STARD3 phosphorylation (Fig

ERCC6, a member of a subfamily of putative helicases, is involved in Cockaynes syndrome and preferential repair of active genes