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Mild Diarrhea: Some people might experience gastrointestinal discomfort, including diarrhea, after receiving B12 shots

These include mild soreness, redness, or a warm sensation at the injection site, brief lightheadedness or flushing shortly after administration, and occasional mild nausea in the first few sessions as the body adjusts to the lipotropic compounds

Patients who have normal intestinal absorption may be treated with an oral therapeutic multivitamin preparation, containing 15 mcg vitamin B12 daily

A vegan diet is generally healthy, low in cholesterol and protective of heart disease, but its followers must take vitamin B12 supplements or risk a condition that causes permanent numbness in their hands and feet, experts say

In a post hoc analysis after 13 years of the study, a 13% increased risk of vitamin B12 deficiency per year of metformin use was reported (Aroda et al, 2016)