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Next, we used proteomics results to stratify COPD patients into 3 subgroups (Table 3): subtype I were mainly COPD without other respiratory diseases (simplex COPD, n = 19), subtype II largely for COPD co-existing with bronchiectasis (COPD-BE, n = 9), and subtype III focused on COPD co-existing with metabolic syndrome (COPD-MD, n = 12)

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