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41 Dangerous stimuli such as pathogen invasion initiate innate immune responses, and dynamically encode specific information such as ligand dose, duration, and distance through wave propagation of NF-B signaling, forming gene expression regions in response cells

Additionally, TGF- is essential for regulating macrophage recruitment and function in fibrotic lesions, acting as a chemoattractant for these cells to fibrotic sites (101)

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Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)

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