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Furthermore, the expression of M1-related cytokines (IL-6, IL-1, and TNF-) was reduced in an inflammatory macrophage cell model, while phosphorylation of proteins associated with the MAPKs pathway such as ERK and JNK was significantly inhibited in RAW264.7 cells

Specific hormones or growth factors predominantly exert their anti-inflammatory effects on intestinal innate immunity through their action on the proliferation and differentiation of IECs and immune cells (lymphocytes and macrophages) and modulating the inflammatory cytokine response

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