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Small-molecule NNMT inhibitor (5-amino-1-methylquinolinium) The pathways 5-Amino-1MQ acts on and what each one does

Researchers reported that NNMT inhibition affected senescent muscle-stem-cell activity and selected measures of regenerative capacity after experimental injury

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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear